DOXY PEP
(Doxycycline Post-Exposure Prophylaxis)
 

Doxycycline is an antibiotic that can help prevent the development of chlamydia, syphilis, and gonorrhoea when taken shortly after exposure to these infections. It works by killing or inhibiting the growth of the bacteria that cause these STIs.

 

Doxy PEP involves taking an antibiotic after a possible exposure, and is most effective when taken within 72 hours of exposure. While it can significantly reduce the risk of infection, it is not guaranteed to prevent transmission in all cases.
 

Doxy PEP is recommended for individuals who are at high risk of contracting these infections following unprotected sex or other potential exposures to infected bodily fluids.

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WHO CAN TAKE DOXY PEP?

 

• Current evidence supports the use only for:

  • Cisgender men who have sex with men

  • Transgender Women 

• Sexual practices that may put you at risk

• No allergies to Doxycycline (or Tetracycline) medication
   

WHEN SHOULD I TAKE DOXY PEP?

• Doxy PEP should be taken within 72 hours (3 days) of the exposure for the best chance of preventing infection.

• It’s most effective when taken as soon as possible after possible exposure.

 

HOW DO I TAKE DOXY PEP?

• Your healthcare provider will prescribe 200 mg of Doxycycline, typically taken as a single dose (two 100 mg capsules/tablets).

• Take each dose with food

• Do not lay down for at least 45 minutes after taking a dose

• Drink a large glass of water immediately after taking each dose

POSSIBLE SIDE EFFECTS OF DOXY PEP:

The most common side effects include:

• Nausea or upset stomach

• Diarrhea

• Headache

• Sun sensitivity (increased risk of sunburn)

• Esophageal irritation (pain or difficulty swallowing), especially if you do not drink enough fluids with the pill.
   

Less common but serious side effects include:

• Severe allergic reactions (rash, swelling, trouble breathing)

• Severe abdominal pain or persistent diarrhea (which may indicate an intestinal infection)

• If any of these side effects occur, please contact your health care provider immediately, or visit your nearest emergency department. 

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WHAT ELSE SHOULD I KNOW?
 

• While studies are currently ongoing in several parts the world, the medication is currently NOT APPROVED by Health Canada, and available on an individual case-by-case basis and with off-label consent.
   

• Drug interactions: Doxycycline may interact with other medications (including antacids, some blood thinners, and other antibiotics). Make sure to tell your healthcare provider about all the medications you are taking.
   

• Allergies: If you are allergic to tetracyclines (a class of antibiotics that includes Doxycycline), you should not take Doxy PEP.
   

• Follow-up is important: Even if you take Doxy PEP, you should follow up with your healthcare provider for further STI testing. Some infections may not show symptoms right away.
   

• Doxy PEP is not a substitute for STI testing or using other preventive methods: Regular use of condoms or PrEP (pre-exposure prophylaxis) for HIV, as well as routine STI testing, remains important in reducing your risk.
   

HOW DO I GET IT?

Book a DOXY PEP appointment to discuss with a health care provider & receive a prescription. It is covered under OHIP+ (if you are 24 and under), or if you have private insurance benefits. If not, it is a relatively inexpensive medication and you can discuss quantity and dosing with your provider when you come in for your appointment.